Rituximab and JC virus-PML association

Rituximab and JC virus-PML associatio Dr. Noa Shcwartz Back to your profile Research Inquiry Progressive multifocal leukoencephalopathy (PML) is a CNS infection caused by the JC virus, which commonly establishes a persistent, asymptomatic infection in the general population1. PML classically occurs in patients with severe immunodepression, and cases have recently been linked to therapeutic monoclonal […]

RNF168 mutation and autoimmunity

RNF168 mutation and autoimmunity Dr. Noa Shcwartz Back to your profile Research Inquiry Is there any known association between heterozygous RNF168 mutation and autoimmunity? Conclusion​ According to our research which included searching the known, famous genetic libraries (e.g. OMIM), as well as a literature review in PubMed, we couldn’t find an obvious connection – neither experimentally/theoretically […]

PML with Rituximab infusions

PML with Rituximab infusions Dr. Noa Schwartz Back to your profile Research Inquiry What is the data about PML with Rituximab infusions for rheumatologist indications? Would screening for JC virus in the blood be useful in preventing PML cases in this population? Medical Meta Findings​ Progressive multifocal leukoencephalopathy (PML) is a significant neurological disease  caused […]

Saphnelo Review

Saphnelo Review Dr. Noa Schwartz Back to your profile Research Inquiry Review the recently approved drug Saphnelo (anifrolumab-fnia). This review will address indications, contra-indication, efficacy evidence, real-world reports, and additional relevant data. Conclusion​ This report contains data and information as published by AstraZeneca, the regulatory authorities, and the scientific medical journals. As this drug was […]

Cellcept and Breastfeeding

Cellcept and Breastfeeding Cellcept and Breastfeeding Back to your profile Research Inquiry Mycophenolate mofetil (MMF, CellCept) is an immunosuppressant medication that, in combination with corticosteroids and either ciclosporin or tacrolimus, is indicated for the prevention of organ rejection in patients receiving kidney, heart or liver transplants. It is also indicated for the treatment of patients […]

Still’s disease possible treatments

Still’s disease possible treatments Dr. Noa Schwartz View as PDF Back to your profile Research Inquiry The patient is a 21-y/o woman with Still’s disease. She has been treated so far with anakinra, tocilizumab, MTX, and tacrolimus with no sufficient improvement. Medical Meta Findings​ The treatments presented in this section are the most significant therapy […]